Studies & Clinical Trials

Dietary Supplement

Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients

To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell Disease

Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia

A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT

Behavioral Intervention

Drug Intervention

Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects With Stable Sickle Cell Disease

Minimizing Toxicity in HLA-identical Related Donor Transplantation for Children With Sickle Cell Disease

Intranasal Ketamine For Pain Control In Patients With Sickle Cell Disease And Vaso-occlusive Episode (VOE) In The PED

Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease

Sleep and Pain in Sickle Cell Disease

Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell Disease

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

FOCUS for Pediatric Sickle Cell Disease and Cancer

The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENT

Hydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy Trial

HRV-B for Symptom Management in Sickle Cell Patients

Shared-Decision Making for Hydroxyurea

Laboratory-based Hypnosis Intervention on Pain Responsivity in Adolescents With Sickle Cell Disease

Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea Utilization

iPeer2Peer Program for Youth With Sickle Cell Disease

Patient Centered Comprehensive Medication Adherence Management System in Patients With Sickle Cell

iCanCope With Sickle Cell Pain

Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic

Specifying Interventions From the Sickle Cell Disease Implementation Consortium (SCDIC)

Biological

Sickle Cell Anemia WE CARE

CSL200 Gene Therapy in Adults With Severe Sickle Cell Disease

T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation

A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease

Stem Cell Transplant in Patients With Severe Sickle Cell Disease

Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease

Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

Assessing the Safety of Buprenorphine in People With Sickle Cell Disease

Stem Cell Transplant in Sickle Cell Disease and Thalassemia

Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)

Outcomes Mandate National Integration With Cannabis as Medicine

Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease

Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease

Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients

A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism

Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

A Blood Stem Cell Transplant for Sickle Cell Disease

Daily Vitamin D for Sickle-cell Respiratory Complications

RHD Genotype Matching for Anti-D

Allograft for Sickle Cell Disease and Thalassemia

Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease

Stem Cell Gene Therapy for Sickle Cell Disease

A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell

The Impact of Oxidative Stress on Erythrocyte Bilogy

Age of Blood in Sickle Cell Transfusion

Gene Transfer for Sickle Cell Disease

Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)

RH Genotype Matched RBC Transfusions

TAPS2 Transfusion Antenatally in Pregnant Women With SCD

Device

Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor

Long-term Safety and Efficacy of FerriproxÂ® in Iron Overloaded Patients With Sickle Cell Disease or Other

Efficacy and Safety of FerriproxÂ® in Patients With Sickle Cell Disease or Other Anemias

Deferoxamine for Sickle Cell Chronic Leg Ulcer Treatment

Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease

Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome

Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease

Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease

Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease

Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplant for Sickle Cell Disease

A SAD/MAD to Assess the Safety, Pharmacokinetics and Pharmacodynamics of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients

Study to Evaluate the Effect of GBT440 in Pediatrics With Sickle Cell Disease

Hydroxyurea and Transfusion

Hydroxyurea Optimization Through Precision Study

Therapeutic Response Evaluation and Adherence Trial (TREAT)

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease

Sickle Cell Disease, Hemechip

Evaluation of HemoTypeSC as a Novel Rapid Test for Point-of-Care Screening for Sickle-Cell Disease, Hemoglobin C Disease, and Carrier Status in Low-Resource Settings

Hyperbaric Oxygen Therapy in Sickle Cell Pain

Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell Disease

Diagnostic

Near Infrared Spectroscopy in Sickle Cell Pediatric Patients

Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant

Procedure

Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With

Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced

Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)

Management of Severe Acute Malnutrition in SCD, in Northern Nigeria

Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)

Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia

Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT

Hydroxyurea Therapy: Optimizing Access in Pediatric Populations Everywhere

Imatinib for Pain in Sickle Cell Anemia

Intravenous Gammaglobulin for Sickle Cell Pain Crises

An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia

A Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-Î²0 Thalassemia)

A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)

Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises

Arginine Therapy for Sickle Cell Disease Pain

Preventing Sickle Cell Kidney Disease

Macitentan in Pulmonary Hypertension of Sickle Cell Disease

Fetal Hemoglobin Induction Treatment Metformin

Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant Diseases

Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow

Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMT CTN 1507)

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation

A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease

A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease

Nitrous Oxide Analgesia Vaso-occlusive Crisis

Haploidentical Hematopoietic Stem Cell Transplantation

Inhaled Mometasone to Promote Reduction in Vasoocclusive Events 2

Cardiovascular Complications of Sickle Cell Disease

Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

Other

Gene Transfer for Patients With Sickle Cell Disease

Microvascular and Fibrosis Imaging Study

Acupuncture for Adults With Sickle Cell Disease (SCD): A Feasibility Study

Acupuncture for Pain in Sickle Cell Disease

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Haploidentical Hematopoietic Stem Cell Transplantation

Arginine Therapy for Sickle Cell Disease Pain

Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease

Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease

Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)

Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

Rifaximin to Modify the Disease Course in Sickle Cell Disease

A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases

A Sickle CEll Disease ComplicatioN Trial

Dose-Escalation Study of SCD-101 in Sickle Cell Disease

A Study of SHP655 (rADAMTS13) in Sickle Cell Disease

Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

Non-Myeloablative Conditioning and Bone Marrow Transplantation

Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

Pediatric Open-Label Extension of Voxelotor

Arginine Therapy for Sickle Cell Disease Pain